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Nisin is a polycyclic antibacterial peptide produced by the bacterium Lactococcus lactis that is used as a food preservative. Nisin is a natural, toxicologically safe, anti bacterial food preservative.
【Basic Information】
【Chemical Name】NISIN
【CAS No.】1414-45-5
【EINECS No.】215-807-5
【E No.】E234
【Specification】Food Preservatives
【Molecular Formula】C143H230N42O37S7
【Formula Weight】3354.0705
【Storage】Term of validity: two years in cool (0oC - 10oC is recommended), dry conditions, away from direct sunlight in original unopened packs.
【Chemical Properties】Nisin is white color powder with hydrous potency 1000IU/mg. It is stable in room temperature and acidity condition even heated. It can endurance 30 min in pH=2.0 、 121 ℃ and 15 min in pH=3.0 、 121 ℃ . But at the high pH, the stability of activity can be greatly affected.
【Other Names】 L-Isoleucyl-(Z)-2,3-didehydro-2-aminobutanoyl-D-cysteinyl-L-isoleucyl-2,3-didehydroalanyl-L-leucyl-L-cysteinyl-threo-3-mercapto-D-2-aminobutanoyl-L-prolylglycyl-L-cysteinyl-L-lysyl-threo-3-mercapto-D
【Commercial Information】
【Packing】100g/bottle,500g/bottle.1kg/bottle,25kg/drum,40kg/drum
【Shelf Life】2 years
【Delivery】Within 15 days of order date
【Payment】T/T, D/P, L/C
【Origin】China
【Brand】VIADD
【Supplier】Shenyang Viadd Chemical Co.,Ltd.
【Price Email】sales@viaddchem.com
【Certificate】ISO,KOSHER,HALAL,GMP, MSDS, Material Data Sheet, Non GMO,Non Allergen
【Deliver Port】Tianjin/Qingdao
【Documents】Sales Contract, Commercial Invice, Packing List, Weight List, COA, , Cetificate of Origin, Healthey Certificate, FORM A, FORM E, Policy of Indusrance, B/L, Loading container photos, packing photos, shipping advice, etc
【Application of Nisin】
Nisin can be used in a wide range of heat-processed foods. These include: fresh milk, processed cheese and other dairy products, pasteurised liquid egg, processed meat, seafood, canned food, fruit drinks, plant protein drinks, baked products, instant food, beer, wine ect. It can also be used as a preservative in gelatin processing, cosmetics, drugs and health products.
【Usages method of NISIN】
The recommended dosage of NisinPro is in the range 20-500mg per kg or litre of food. Exact dosage can not be stated as it depends on the nature of the product for which it is intended. NisinPro should be added to heat processed foods by thorough dispersion in the food substrade prior to the heating process. NisinProcan be added directly to the food as a dry powder or as a pro-suspension in water or milk. In certain processing situations there may be potential for adding NisinPro by other methods, such as dipping or after a fermentation process, e.g. stirred yoghurt. Advice should be sought for these more specialized food application areas.
【Specification of Ninsin】
ITEM |
STANDARD |
Appearance |
Light brown to cream white powder |
Potency (IU/ mg) |
1000 Min |
Loss on drying (%) |
3 Max |
pH (10% solution) |
3.1- 3.6 |
Arsenic |
=< 1 mg/kg |
Lead |
=< 1 mg/kg |
Mercury |
=< 1 mg/kg |
Total heavy metals ( as Pb) |
=< 10 mg/kg |
Sodium chloride (%) |
85 |
Total plate count |
=< 10 cfu/g |
Coliform bacteria |
=< 30 MPN/ 100g |
E.coli/ 5g |
Negative |
Salmonella/ 10g |
Negative |
【Product Advantages】
1 Can effectively inhibit the Gram-positive bacteria, such as heat resistance of Bacillus, Clostridium botulinum, Listeria and its produced spores, also inhibit some Gram-negative bacteria
2 To ensure food quality, extend the shelf life of food
3 Good thermal stability, less loss of activity after heat treatment
4 low dosage, to save much cost.
5 replace some chemical preservatives, to meet the needs of customers and consumers for natural preservatives
【Features of NISIN】
1.Strong inhibiting activities. Nisin specifically targets the stubborn Bacillus spp. and their spores.
2.High safety. Nisin can be quickly digested into amino acids with the aid of enzymes in human stomach.
3.Good stability. Nisin is stable in acid conditions and can keep active even at 121℃ for 30mins.
4.Easy water soluble.
5.No flavor influence.
【Dosage used in food of NISIN】
Application range and the maximum usage in food
Food applications |
Antiseptics Nisin use dosage(g/kg g/L) |
Milk and dairy products (except 13.0 special nutritional food involves varieties) |
0.3~ 0.5 |
Pasteurized milk and dairy products |
0.3 ~ 0.4 |
Pasteurized cold soup |
0.1 ~ 0.2 |
muffin |
0.15 ~ 0.25 |
Canned food (high acid) |
0.1 ~ 0.2 |
Ricotta Cheese |
0.2 ~ 0.5 |
Continental cooked sausage |
0.2 ~ 0.5 |
Dipping sauce |
0.05 ~ 0.25 |
Salad dressing |
0.05 ~ 0.2 |
Beer, fermented drinks and wine |
0.01 ~ 0.05 |
Vinegar |
0.05 ~ 0.15 |
Soy sauce |
0.05 ~ 0.2 |
【Packing of NISIN】
【Is NISIN safe?】
Nisin is non-toxic and the producer strains of L. lactis are regarded as safe (food-grade); there is no apparent cross-resistance in bacteria that may affect antibiotic therapeutics; and it can be quickly digested into amino acids by enzymes in human intestines and stomach.