Food & Feed Additives
2. 【Other Name】3-(4-Hydroxyphenyl)-L-alanine; H-Tyr-OH; L-tyrosine,99+% (98% ee/glc); L-tyrosine free base cell culture*tested; L-tyrosine plant cell culture tested; L-Tyrosine, Free Base; tyrosine usp; Tyr
3. 【CAS】60-18-4
4. 【EINECS NO】200-460-4
5. 【HS CODE】29225000
6.【Package】 25kg craft paper bag or drum, as you demand
7.【Standard: 】AJI92, AJI97, EP, USP30, USP32,USP36
8.【Shelf Life】 Two years if properly stored.
Email: sales@viaddchem.com
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ABOUT L-TYROSINE
VIADD CHEMICAL company is one professional L-Tyrosine supplier, distibutor and exporter from China, welcome get L-Tyrosine price by email: sales@viaddchem.com
L - tyrosine belongs to a kind of amino acids, crystalline powder, from casein or extract, hydrolyzed protein material such as corn is non-essential amino acids the human body. Medicine as a treatment for thyroid function hyperfunction, can also be as a food additive.
L-tyrosine is an amino acid which is used by the body to make dopamine, a brain chemical that makes you feel good.
【Product Name】L-Tyrosine
【CAS】60-18-4
【Other Name】3-(4-Hydroxyphenyl)-L-alanine; H-Tyr-OH; L-tyrosine,99+% (98% ee/glc); L-tyrosine free base cell culture*tested; L-tyrosine plant cell culture tested; L-Tyrosine, Free Base; tyrosine usp; Tyr
【Synonyms】3-(4-HYDROXYPHENYL)-L-ALANINE;2-Amino-3-(4-hydroxyphenyl)-propanoic acid;2-AMINO-3-(P-HYDROXYPHENYL)PROPIONIC ACID;4-HYDROXYPHENYLALANINE;FEMA 3736;H-L-TYR-OH;H-TYR-OH;L-3-[4-HYDROXYPHENYL]ALANINE
【Molecular Structure】
【EINECS NO】200-460-4
【HS CODE】29225000
【MOLECULAR FORMULA】C9H11NO3
【MOLECULAR WEIGHT】181.19
【Package】 25kg craft paper bag or drum, as you demand
【Standard: 】AJI92, AJI97, EP, USP30, USP32,USP36
【Shelf Life】 Two years if properly stored.
【Storage situation】Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
【Chemical Properties】
White needle crystal or crystalline powder, odorless, bitter taste, mp334 ℃ (decomposition) is insoluble in water (0.04%, 25 ℃), insoluble in ethanol, ether and acetone, soluble in dilute acid or base . The isoelectric point of 5.66.
【Product Categories】Inhibitors;Food and Feed Additive;Tyrosine [Tyr, Y];Amino Acids;Amino Acids and Derivatives;alpha-Amino Acids;Biochemistry;Nutritional Supplements;L-Amino Acids;Amino Acids;NORCURON;amino
【Applications】
1.Tyrosine is a naturally occurring amino acid that is also available in supplement form.
2.Tyrosine is a nonessential amino acid (the body can produce it on its own) and it's nutrient role is as a neurotransmitter, which act as chemical messengers to the body's 100 billion (or more) of nerve and brain cells.
3.Tyrosine helps form three important neurotransmitters: serotonin, dopamine, and norepinephrine;these are responsible for functions like memory, mood, appetite, and muscular coordination.
4. Clinical studies have shown that Tyrosine supplements help with depression, anxiety, and heighten the mood in just a matter of a few weeks.
【Specificaitons】
|
Item |
Specifications |
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USP24 |
AJI97 |
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Appearance |
White crystals or crystalline powder; tasteless |
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Assay,% |
98.5~101.5 |
99.0~101.0 |
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Specific optical rotation |
-9.8°~ -11.2° |
-11.3°~ -12.1° |
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Transmittance, % |
- - - |
≥98.0 |
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Heavy Metals (as Pb), % |
≤0.001 |
≤0.001 |
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pH value |
- - - |
5.0~6.5 |
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Loss on drying, % |
≤0.3 |
≤0.2 |
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Residue on ignition, % |
≤0.4 |
≤0.1 |
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Chloride (as Cl),% |
≤0.04 |
≤0.02 |
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Ammonium (as NH4),% |
- - - |
≤0.02 |
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Sulfate (as SO4), % |
≤0.04 |
≤0.02 |
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Iron, % |
≤0.003 |
≤0.001 |
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Arsenic (as As), % |
≤0.0001 |
≤0.0001 |
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Other amino acids |
- - - |
Not detd. |
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Organic volatile impurities |
Meets the requirement |
- - - |
【Uses】
L-Tyrosine is one of the 22 proteinogenic amino acids that are used by cells to synthesize proteins. L-Tyrosine is biologically converted from L-phenylalanine and is in turn is converted to L-DOPA and further converted into the neurotransmitters: dopamine, norepinephrine, and epinephrine.
【Limited Use】
4.3% by weight of total protein foods (FDA, §172.320,2000).
FEMA: bakery products, meat products, snack foods, condiments, seasoning flavoring products are 250mg/kg.
The maximum amount permitted of food additives maximum allowable residue limits Chinese name of the food additive Chinese name of food allowed to use the food additive function of the additive permitted maximum amount (g/kg) maximum allowable residues (g/kg) L-Tyrosine food spices for food flavor preparation should not exceed the maximum allowable amount and the maximum allowable residues of each perfume ingredient
in the GB 2760
【What is L-Tyrosine】
Tyrosine is found by Li Biqi 1846 from casein, white crystalline powder, needle-like crystals or platelets from the water. The relative density of 1.456 (20 ℃), the isoelectric point of 5.66, UV absorption capacity, at a wavelength of 274nm of maximum light absorption, capable of reducing phosphomolybdic acid-phosphotungstic acid reagent (Folin reagent). Melting point: L-body decomposition 290~295 ℃ (slow heating), decomposition (rapid heating) 314~318 ℃, the racemate 290 to 295 decomposition (slow heating), decomposition (rapid heating) 340 ℃. Soluble in water, alcohol, acid and alkali, insoluble in ether. Dextrose solution reacts with tyrosinase to be red. laevo isomer friction can emit light , when at 170 ℃ heated with the barium hydroxide solution ,it can become a racemate, ortho of the phenolic hydroxyl group of tyrosine molecule is prone to chemical reaction, when coupled with a diazonium acid ,it is orange-red substance, when coupled with boiling dilute acetic acid and sodium nitrite ,it is purple or red, yellow when coupled with nitric acid, when in sulfuric acid reacting with titanium dioxide it is dark orange. L-tyrosine is a natural body, by proteolysis, refining.
Tyrosine is a non-essential amino acid, is the material of a variety of body products, tyrosine is converted in vivo to a variety of biological substances by different metabolic pathways, such as dopamine, epinephrine, thyroxine, and melanin poppy (opium ) of papaverine. These substances and control neurotransmission and metabolism are closely related. Tyrosine Metabolism studies help to understand the pathogenesis of certain diseases. For example, urine black acid syndrome is related to tyrosine metabolic disorders, lack of urinary black acid oxidase in the patients causes tyrosine metabolite which is urine black acid can not continue to break down, when the air is discharged from the urine,it becomes black oxidation substance in the air. suffering from this disease, children's diapers exposed to air will gradually turn black, long home of urine also will be black. Albinism is also concerned with the metabolism of tyrosine, patients lacking tyrosinase makes tyrosine metabolites-3,4-dihydroxyphenylalanine impossible to form melanin so that the skin hairs are white.
【Safety Information】
Hazard Codes : Xi
Risk Statements : 36/37/38-40
Safety Statements : 26-36-37/39-22
WGK Germany : 3
RTECS: YP2275600
TSCA : Yes
HS Code :29225000
Hazardous Substances Data:60-18-4(Hazardous Substances Data)
【Raw Materials】
Α-PROTEIN-->Ethylenediaminetetraacetic acid-->Casein-->Boc-D-Tyrosine-->SILK-->Hydroxyapatite
【Production Method】
after precipitation of the casein, silk and other protein acid hydrolyzates,dissolve in dilute aqueous ammonia, with acetic acid neutralize to pH = 5, recrystallization to derive it. Extract The pig hydrolyzate to get second crude liquid crystalline pure cystine, store two days at 20 ℃, tyrosine precipitation, filtration, available tyrosine crude, refine also to receive L-Tyrosine . 1% Of pig yield.
Casein as raw materials, reflux for several in hourshydrochloric acid , filter, and concentrate, soda and charcoal, crystallize,obtain products.
Production of L-Tyrosine mainly takes proteolysis extraction. blood meal, hoof angle, silk and other raw materials, acid hydrolysis, separation and purification.
Blood meal [HCl (hydrolysis)] → [110 ℃, 24h] hydrolyzate [rush acid] → [concentrated by evaporation] In addition to the acid [charcoal] → destaining solution [bleaching, cooling and crystallization] → L-Tyrosine crude [Activated Carbon (refined)] → [90 ℃, 30min] filtrate [crystalline] → L-tyrosine.
Hydrolysis, rush acid the blood meal, water, industrial hydrochloric as 1: 1.3: 1 ratio by weight, respectively put into the hydrolyzed cylinder, heat to 112-114 ℃, stop after 24h of stirring under reflux , cool and filter to remove, give filtrate which is hydrolyzate . The hydrolyzate is concentrated by evaporation to a syrup, add water to dissolve ,oncentrated by evaporation, so repeat three times to rush the acid.
Bleaching, crystallized concentrate is diluted with distilled water to the whole solution,add aqueous ammonia solution to pH 3.5, 1% charcoal is added, boiling with stirring 10min, stirring in a water bath at 90 ℃ incubated 30min, filter while hot, active carbon layer is washed with distilled water 3 times, and the filtrate and washings are combined. According to the Act, continue to use active carbon to make the solution pale yellow. The filtrate is placed in quiet place below 10 ℃ 24h, ie, crystalline precipitation, filtration to obtain crude L-tyrosine.
Recrystallized tyrosine crude 1:20 distilled water is added, after the whole solution, plus 1% activated carbon, 90 ℃ insulation mixing 30min, filter hot and the filtrate cool to refined crystallize . The crystals are collected by filtration, washed with anhydrous ethanol twice, 60 ℃ drying, the finished product is L-tyrosine.
