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What is L-Citrulline

 What is L-Citrulline?

L-citrulline is a non-essential amino acid, meaning it’s naturally made in the body and therefore not an essential part of the diet.

Its name is derived from Citrullus vulgaris, the Latin word for watermelon, from which it was first isolated. Other food sources include cucumbers, pumpkins, muskmelons, and squashes.

As a dietary supplement, it can be taken as free-form l-citrulline or citrulline malate, which is l-citrulline bound to malic acid. Both forms are equal for the purposes of increasing blood arginine levels and nitric oxide, but citrulline malate is more common in sports supplements.

1.8 g of citrulline malate is equal to 1 g of free-form citrulline, due to the weight of the malate molecule.

 

Main Functions                              


1.improve immune system function.

2.Maintenance of functional joint movement.

3.Normal blood sugar levels balanced

4.Rich in antioxidants to absorb harmful free radicals

5.Help maintain normal cholesterol levels.

6.Maintaining our health lung function

7.Improve mental clarity

8.Reduce stress and overcome frustration

 

Dosage:
The recommended daily supplemental dose of L-Citrulline is 200-1000 mg once a day before bed (at the same time of the day when you ought to be taking your L-Arginine supplement). L-Citrulline supplements may be difficult to find on their own as they are most likely going to be combined with L-Arginine or included as a part of a collection of supplements meant to do a number of specific things. This is why the dosage amount can vary so greatly. The lowest recommended daily dose is the 200 mg while the most that you will want to take in a 24 hour period should not exceed 1000 mg. You will need to keep this in mind especially if thus supplement is combined with other supplements that are taken in high doses or more than once throughout the day.



 Application                                  



1.L-citrulline is a naturally occurring amino acid, it is found in some foods like watermelons and is also produced naturally by the body.

2.L-citrulline is used for Alzheimer’s disease, dementia, fatigue, muscle weakness, erectile dysfunction, high blood pressure, and diabetes.

ISO Factory Supply Food Grade L-CitrullineISO Factory Supply Food Grade L-Citrulline

3.L-citrulline is used for heart disease, body building,

increasing energy, and for improving athletic performance.

 

 Knowledge of L-Citrulline                              


How L-Citrulline Works

Supplementing with l-citrulline increases levels of arginine in the blood, which increases the production of a molecule called nitric oxide.

This important signaling molecule is involved in many cell processes, including vasodilation, or widening of the blood vessels. Wider blood vessels means increased delivery of nutrients and oxygen to the working muscles during exercise, enhancing muscle growth and muscle recovery.

L-arginine is also a common supplement marketed to increase nitric oxide production. But l-citrulline supplementation increases levels of l-arginine in the body more than supplementing with l-arginine itself. This is because the majority of l-arginine (nearly 40%) is broken down in the small intestines and liver before it gets a chance to reach the bloodstream.

On the other hand, l-citrulline is not metabolized by the intestines or liver, leaving roughly 80% of the ingested dose to be converted to l-arginine and nitric oxide.

L-citrulline also plays a role in the urea cycle, which eliminates ammonia from the body. Intense exercise triggers ammonia production which is a major contributor to muscle fatigue. Therefore, supplementing with l-citrulline may increase the time to fatigue.

What Exercises Is L-Citrulline Effective For?

More research is needed to determine what kind of exercises would benefit the most from L-citrulline supplementation.

The current research suggests l-citrulline is most effective for short-lasting, high-intensity exercises like weight lifting or repeated sprints. Supplementation can also decrease muscle soreness from these exercises.

Those involved in long duration endurance activities are likely to benefit most from l-citrulline malate supplementation. Malate plays an important role in energy production and therefore may work synergistically with l-citrulline to improve physical stamina.

How to Supplement L-Citrulline

More research is also needed to determine optimal dosing protocols, since studies investigating l-citrulline and exercise use different supplementation protocols.

Two studies have used a single six gram dose of citrulline malate two hours before endurance exercise (1, 2), and four studies have used a single dose of citrulline malate one hour before resistance training (1, 2, 3, 4). All of the studies found positive results.

Therefore, six to eight grams of citrulline malate, or about three to four grams of free-form l-citrulline, taken an hour or two before exercise is likely an efficacious supplementation protocol.

Citrulline Benefits

Citrulline promotes blood circulation and the release of human growth hormone. This can increase resistance to injury and illness. The supplement supports high functioning immunity in all systems of the body. It speeds recovery from cuts and surgeries. It also contributes to bone strength.

L-Citruline is an excellent therapy for high blood pressure. For mens’ sexual health, the compound is thought to have similar effects of prescription drug Viagra. In the brain, more circulation and oxygen results in sharper, clearer thoughts.

Short term memory, long term memory, and recall are all enhanced. It has been suggested as a natural treatment for Parkinson’s Disease, as it may help those patients achieve a higher degree of mental control.

Is L-Citrulline Safe?

L-citrulline, unlike l-arginine, is well-tolerated in large doses. In clinical trials, l-citrulline has been used safely for up to nine months, in doses up to 0.13 g/kg/day, about nine grams for a 155-pound person. Doses up to 15 g have also been used.

 

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